Title: Investigating the relationship between type 2 diabetes and atherosclerotic cardiovascular disease using Mendelian randomization
Speaker: Venexia Walker, University of Bristol
Abstract:
Type 2 diabetes and atherosclerotic cardiovascular diseases, such as coronary and peripheral artery disease, share many risk factors. Furthermore, atherosclerotic cardiovascular diseases are common complications following a type 2 diabetes diagnosis. During this talk, I will discuss two studies that use Mendelian randomization in different ways to investigate the relationship between these complex traits. The first study uses two-step Mendelian randomisation for mediation to separate the direct effects of a broad range of continuous traits on coronary and peripheral artery disease from those mediated by type 2 diabetes. The second study uses Mendelian randomization to identify risk factors for progression from type 2 diabetes to atherosclerotic cardiovascular disease and involves the application of newly developed methods to account for the potential index event bias that can occur when using case-only phenotypes.
Venexia Walker, University of Bristol